Understanding how specific RNA modifications affect sperm development
Epitranscriptomic control of mRNA and noncoding RNAs in spermatogenesis
['FUNDING_OTHER'] · CORNELL UNIVERSITY · NIH-11083781
This study looks at how tiny changes in RNA affect the development of sperm from stem cells, aiming to understand what helps or hinders this process, which could lead to new ways to improve fertility for those facing challenges in having children.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-11083781 on ClinicalTrials.gov |
What this research studies
This research investigates the role of epitranscriptomic modifications in the process of spermatogenesis, which is the development of sperm from stem cells. The study focuses on how changes in RNA molecules, particularly in their 3' untranslated regions, influence the differentiation of spermatogonial stem cells into mature sperm. By mapping specific RNA modifications in a detailed and quantitative manner, the research aims to uncover the mechanisms that regulate sperm development and identify potential targets for improving fertility. Patients may benefit from insights gained regarding the causes of infertility related to sperm development.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing difficulties conceiving due to potential issues in sperm development.
Not a fit: Patients who are not experiencing infertility or have other unrelated reproductive health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating male infertility.
How similar studies have performed: While the specific focus on epitranscriptomic modifications in spermatogenesis is relatively novel, related research has shown promising results in understanding RNA modifications and their impact on fertility.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAFFREY, SAMIE R — CORNELL UNIVERSITY
- Study coordinator: JAFFREY, SAMIE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.