Understanding how specific RNA changes affect cell behavior during development and cancer.
Comprehensive identification and functional study of Esrp-regulated isoforms during epithelial-mesenchymal transition.
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11140878
This study is looking at how certain proteins affect the way genes are switched on and off during important processes like development and cancer, which could help us understand conditions like orofacial clefts and lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11140878 on ClinicalTrials.gov |
What this research studies
This research investigates the role of alternative RNA splicing in the process of epithelial-mesenchymal transition (EMT), which is crucial for normal development and cancer progression. By using advanced sequencing technologies, the study aims to identify and characterize the various RNA isoforms regulated by Epithelial-splicing regulatory proteins (ESRP1/2). The goal is to understand how these isoforms contribute to conditions like orofacial clefts and other developmental anomalies. Patients may benefit from insights that could lead to improved diagnostics and therapies targeting these molecular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with orofacial clefts or related developmental disorders, as well as patients with cancers where EMT plays a significant role.
Not a fit: Patients with conditions unrelated to RNA splicing or EMT may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with developmental anomalies and certain cancers.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing and its implications in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIAO, ERIC CHIEN-WEI — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: LIAO, ERIC CHIEN-WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.