Understanding how specific regions in DNA affect T cell development
Official title: Characterization of the roles of bivalent domains in CD4+ T cell differentiation
Funded at Howard University · NIH-10301826 · Data updated 2026-11-12
This study is looking at how certain parts of our immune cells, called CD4+ T cells, change and develop, using new technology to see these changes up close, which could help us understand and improve treatments for patients with immune-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Howard University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | March 1, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,955 |
| NIH project number | 1K22HL153477-01A1 |
| Project ID | NIH-10301826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve CD4+ T cell dysfunction or those interested in immune system health.
✕Less likely to help
Patients with conditions unrelated to T cell function or those who do not have immune system disorders may not benefit from this research.
What this research studies
This research focuses on the role of bivalent domains in the differentiation of CD4+ T cells, which are crucial for the immune response. The project utilizes advanced techniques, including a novel assay called iscChIC-seq, to analyze chromatin modifications at the single-cell level. By enhancing the ability to study these modifications, the research aims to uncover how these regions influence T cell behavior and plasticity. Patients may benefit from insights gained into T cell function, which could lead to improved immunotherapies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatments for immune-related conditions.
How similar studies have gone: Other research has shown promise in understanding T cell differentiation through chromatin analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Howard University
Washington, United States Active
Researchers
- Principal investigator: Ku, Wai Lim — Howard University
- Study coordinator: Ku, Wai Lim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.