Understanding how specific regions in DNA affect T cell development
Characterization of the roles of bivalent domains in CD4+ T cell differentiation
This study is looking at how certain parts of our immune cells, called CD4+ T cells, change and develop, using new technology to see these changes up close, which could help us understand and improve treatments for patients with immune-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Howard University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10301826 on NIH RePORTER |
What this research studies
This research focuses on the role of bivalent domains in the differentiation of CD4+ T cells, which are crucial for the immune response. The project utilizes advanced techniques, including a novel assay called iscChIC-seq, to analyze chromatin modifications at the single-cell level. By enhancing the ability to study these modifications, the research aims to uncover how these regions influence T cell behavior and plasticity. Patients may benefit from insights gained into T cell function, which could lead to improved immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve CD4+ T cell dysfunction or those interested in immune system health.
Not a fit: Patients with conditions unrelated to T cell function or those who do not have immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatments for immune-related conditions.
How similar studies have performed: Other research has shown promise in understanding T cell differentiation through chromatin analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- Howard University — Washington, United States (Active)
Researchers
- Principal investigator: Ku, Wai Lim — Howard University
- Study coordinator: Ku, Wai Lim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.