Understanding how specific receptors regulate inflammation in the lungs
Official title: RIG-I-like receptor regulation of pulmonary inflammation and homeostasis
Funded at Ohio State University · NIH-10901970 · Data updated 2026-11-12
This study is looking at how certain receptors in the lungs help control inflammation during illnesses, and it aims to find new ways to treat lung conditions by understanding how these receptors work with the immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM150503-02 |
| Project ID | NIH-10901970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from pulmonary inflammatory diseases or autoimmune conditions.
✕Less likely to help
Patients with non-inflammatory lung conditions or those not affected by immune system dysregulation may not benefit from this research.
What this research studies
This research investigates the role of RIG-I-like receptors (RLRs) in managing inflammation within the lungs during both infectious and non-infectious diseases. By examining how these receptors recognize different nucleic acids, the study aims to uncover their impact on immune responses and tissue repair. The approach includes using synthetic agonists to activate these receptors and studying their effects on immune cell programming and inflammatory signaling. This could lead to new treatment strategies for various inflammatory diseases affecting the lungs.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for treating lung inflammation and related diseases.
How similar studies have gone: Previous research has shown promising results in understanding the roles of immune receptors in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Hemann, Emily Ann — Ohio State University
- Study coordinator: Hemann, Emily Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.