Understanding how specific receptor interactions affect craniofacial development
Characterization of PDGFR dimer-specific dynamics in the craniofacial mesenchyme
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10576282
This study is looking at how certain proteins in our cells might affect the development of the face and skull, which could help us understand why some babies are born with facial birth defects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10576282 on ClinicalTrials.gov |
What this research studies
This research investigates the role of platelet-derived growth factor receptors (PDGFRs) in craniofacial development, focusing on how their interactions can lead to birth defects. By examining the dynamics of PDGFR dimer formation in the craniofacial mesenchyme, the study aims to uncover how these interactions influence gene expression and cell behavior. The researchers will utilize advanced techniques such as fluorescence microscopy and mass spectrometry to analyze these processes in living tissues. This work could provide insights into the biological mechanisms underlying congenital abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with congenital craniofacial abnormalities or those interested in the genetic factors influencing such conditions.
Not a fit: Patients without congenital craniofacial abnormalities or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial birth defects.
How similar studies have performed: Previous research has shown that understanding receptor interactions can lead to significant advancements in treating congenital defects, indicating a promising avenue for this study.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FANTAUZZO, KATHERINE ANN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: FANTAUZZO, KATHERINE ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.