Understanding how specific proteins regulate the development of photoreceptor cells in the retina
Official title: Molecular underpinnings of photoreceptor transcriptional regulation by CRX and NRL
Funded at University of Iowa · NIH-11010382 · Data updated 2026-11-12
This study is looking at how two proteins, CRX and NRL, help keep the light-sensing cells in your eyes healthy, and it hopes to find out how problems with these proteins can lead to eye diseases, which could help develop new treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $388,750 |
| NIH project number | 5R01EY034455-03 |
| Project ID | NIH-11010382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with retinal diseases such as retinitis pigmentosa, cone-rod dystrophy, or Leber congenital amaurosis.
✕Less likely to help
Patients with retinal conditions unrelated to the functions of CRX and NRL may not benefit from this research.
What this research studies
This research investigates the roles of two important proteins, CRX and NRL, in the development and maintenance of photoreceptor cells in the retina. By examining how these proteins interact with DNA, the study aims to uncover the mechanisms behind retinal diseases caused by mutations in these proteins. Patients may benefit from insights gained about how these mutations affect gene regulation, potentially leading to new therapeutic strategies. The research employs advanced techniques to analyze the structures of these protein-DNA complexes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for severe retinal diseases, improving vision and quality of life for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the roles of transcription factors in retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Artemyev, Nikolai O — University of Iowa
- Study coordinator: Artemyev, Nikolai O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.