Understanding how specific proteins regulate enamel formation in teeth
The stage-specific regulation of ameloblastin and enamelin by the distinct nuclear factors
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11082124
This study is looking at how certain proteins help your teeth develop their hard outer layer, which is important for keeping them strong and healthy, and it could lead to better treatments for enamel loss in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11082124 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins in the development of enamel, the hard outer layer of teeth. It focuses on the transition of cells called ameloblasts from a precursor stage to a fully functional state that produces enamel matrix proteins. By studying the genetic and epigenetic factors that control this process, the research aims to uncover how these proteins contribute to the formation and integrity of enamel. This knowledge could lead to advancements in dental treatments and regenerative therapies for enamel loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with enamel-related dental issues or those interested in advancements in dental regenerative therapies.
Not a fit: Patients without any enamel defects or those not seeking dental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dental enamel defects and enhance our ability to regenerate enamel.
How similar studies have performed: Other research has shown promising results in understanding enamel formation and regeneration, indicating that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, YAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: ZHANG, YAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.