Understanding how specific proteins influence the development of brain cells involved in autism and other disorders
Combinatorial function of Foxp1/2/4 in Purkinje cell diversification and cerebellar development
['FUNDING_R01'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-11061121
This study is looking at how certain proteins affect the growth of important brain cells called Purkinje cells, which help with movement and coordination, to better understand their role in conditions like autism and ataxia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-11061121 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, known as Foxp1, Foxp2, and Foxp4, in the development of Purkinje cells, which are crucial for proper cerebellar function. By analyzing the genetic and molecular characteristics of these cells in mice, the study aims to uncover how different subtypes of Purkinje cells contribute to neurodevelopmental disorders such as autism and ataxia. The approach includes advanced techniques like single-cell RNA sequencing and chromatin accessibility assays to identify the unique features of these cell types. This research could provide insights into the underlying mechanisms of cerebellar development and its impact on cognitive functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
Not a fit: Patients with neurodevelopmental disorders not related to cerebellar function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for neurodevelopmental disorders like autism and ataxia.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar proteins in neurodevelopment, indicating potential for success in this area.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, JAMES Y.H — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: LI, JAMES Y.H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.