Understanding how specific proteins influence human cell development
Official title: Defining the role of ILF2-ILF3 in human cell fate
Funded at Baylor College of Medicine · NIH-10997240 · Data updated 2026-11-12
This study is looking at how certain proteins help shape the way our cells grow and change during pregnancy, which could help us understand birth defects better and find new ways to treat them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 5, 2024 |
| Project end | August 4, 2027 |
| Funding year | 2024 |
| Award (this year) | $49,362 |
| NIH project number | 1F30HD114315-01A1 |
| Project ID | NIH-10997240 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are expectant parents concerned about congenital malformations or those with a family history of developmental disorders.
✕Less likely to help
Patients who are not pregnant or do not have a history of congenital malformations may not benefit from this research.
What this research studies
This research investigates the role of ILF2-ILF3 proteins in determining how human cells develop and differentiate during fetal growth. By examining the interactions between DNA and RNA regulation, the study aims to uncover how these proteins influence the fate of embryonic cells. The approach involves manipulating the expression of ILF2-ILF3 to observe its effects on cell identity and development. This could lead to new insights into congenital malformations and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital malformations that arise during fetal development.
How similar studies have gone: Other research has shown promising results in understanding gene regulation in cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Park, Emily J — Baylor College of Medicine
- Study coordinator: Park, Emily J
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to improve genetic diagnosis of congenital heart disease
A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.
-
Surveillance of Vaccine-Preventable Diseases in Children
This project watches how often common vaccines prevent illnesses in kids who are in the hospital or at the emergency department, and compares them with healthy children getting well-child care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Thalamic sleep circuit changes in Alzheimer's disease
Aims to understand how sleep-related brain activity in a key sleep regulator called the TRN affects Alzheimer’s progression and whether boosting TRN function could slow symptoms.
-
Cardiomyocyte-fibroblast signaling in atrial fibrillation
A researcher at Baylor College of Medicine is studying how signals between heart muscle cells and supportive heart cells influence atrial fibrillation, with the goal of finding new ways to prevent or treat this common heart rhythm problem.
-
UMPIRE: Keeping Kidneys Healthy for Babies with Spina Bifida
A care protocol for newborns with spina bifida aims to protect kidney function by thoughtful bladder management and monitoring from birth.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.