Understanding how specific proteins influence heart development
Official title: Regulation of cardiac patterning via Akirin/NuRD Interactions
Funded at Kennesaw State University · NIH-10514703 · Data updated 2026-11-12
This study is looking at how a protein called Akirin helps shape the heart during early development, using fruit flies to learn more about how it interacts with other proteins, which could help us understand heart problems that some babies are born with.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kennesaw State University NIH-funded |
| Lab location | 1 site (Kennesaw, United States) |
| Project start | September 5, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $406,267 |
| NIH project number | 1R15HL161738-01A1 |
| Project ID | NIH-10514703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital heart defects or those with a family history of such conditions.
✕Less likely to help
Patients with congenital heart defects caused solely by environmental factors or non-genetic causes may not benefit from this research.
What this research studies
This research investigates the role of a protein called Akirin in the development of the heart during embryonic stages. By studying the interactions between Akirin and other proteins involved in gene regulation, the researchers aim to uncover how these interactions affect heart patterning and formation. The study uses advanced techniques such as genetic manipulation, biochemical assays, and live imaging to observe these processes in model organisms like fruit flies. The findings could provide insights into the genetic factors contributing to congenital heart defects in humans.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for congenital heart defects.
How similar studies have gone: Previous research has shown success in understanding genetic interactions in heart development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Kennesaw State University
Kennesaw, United States Active
Researchers
- Principal investigator: Bryantsev, Anton — Kennesaw State University
- Study coordinator: Bryantsev, Anton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.