Understanding how specific proteins influence gene regulation in cells
Official title: Investigating the role of PRMT1 and hnRNPK in the spatial regulation of heterochromatin
Funded at University of Pennsylvania · NIH-11068437 · Data updated 2026-11-12
This study is looking at how two proteins help keep our genes organized in the cell's nucleus, which is important for making sure our cells stay healthy and work properly, and it could lead to new treatments for diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM157895-01 |
| Project ID | NIH-11068437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to chromatin dysregulation or those interested in genetic and epigenetic factors affecting cell identity.
✕Less likely to help
Patients with conditions unrelated to chromatin organization or those not affected by gene regulation issues may not benefit from this research.
What this research studies
This research investigates the roles of two proteins, PRMT1 and hnRNPK, in the organization of heterochromatin within the cell nucleus. By examining how these proteins affect the positioning of chromatin at the nuclear periphery, the study aims to uncover mechanisms that maintain cell identity and prevent inappropriate gene expression. The approach includes genome-wide screening and analysis of chromatin modifications, which could provide insights into how these processes are linked to human diseases and development. Patients may benefit from a better understanding of these cellular mechanisms, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatment options for diseases linked to chromatin organization.
How similar studies have gone: Previous research has shown success in understanding chromatin organization and its implications for gene regulation, suggesting that this approach is promising.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kraeutler, Elizabeth — University of Pennsylvania
- Study coordinator: Kraeutler, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.