Understanding how specific proteins influence blood cell development
The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustion
This study is looking at two proteins, MLL3 and MLL4, to see how they help blood cells grow and work properly, which could lead to better understanding and treatments for blood disorders that affect patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11059154 on NIH RePORTER |
What this research studies
This research investigates the roles of two proteins, MLL3 and MLL4, in the development and maintenance of blood cells. By examining how these proteins affect hematopoietic stem cells and their ability to self-renew and differentiate, the research aims to uncover the mechanisms behind blood disorders. The approach involves studying the interactions of these proteins with DNA and other cellular components to understand their impact on blood cell formation and function. Patients may benefit from insights gained into blood diseases and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with blood disorders or those interested in the biological mechanisms of blood cell development.
Not a fit: Patients with non-blood-related conditions or those outside the age range of 21+ years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for various blood disorders.
How similar studies have performed: Previous research has shown success in understanding the roles of transcription factors in blood development, suggesting that exploring epigenetic regulators like MLL3 and MLL4 could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Magee, Jeffrey Alan — Washington University
- Study coordinator: Magee, Jeffrey Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.