Understanding how specific proteins help repair DNA at the ends of chromosomes
Official title: Deciphering the function of cohesin and CTCF in R-loop-mediated DNA repair at telomeres
Funded at North Carolina State University Raleigh · NIH-11070830 · Data updated 2026-11-12
This study is looking at how certain structures in our cells, called R-loops, help repair the ends of our chromosomes, which are important for keeping our DNA safe, especially as we get older, and it’s for anyone interested in understanding how aging and related health issues work.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $40,560 |
| NIH project number | 1F31AG092149-01 |
| Project ID | NIH-11070830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing accelerated aging or related disorders, particularly those with a genetic predisposition to telomere dysfunction.
✕Less likely to help
Patients with no signs of accelerated aging or those without genetic factors affecting telomere function may not benefit from this research.
What this research studies
This research investigates the role of R-loops, which are structures formed by RNA-DNA hybrids, in the repair of DNA at telomeres, the protective ends of chromosomes. It focuses on how proteins called cohesin and CTCF interact with these R-loops to facilitate the DNA damage response, particularly in the context of aging. By using advanced imaging techniques, the research aims to uncover the mechanisms by which these proteins help repair damaged DNA, potentially leading to insights into accelerated aging and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing aging-related diseases by improving our understanding of DNA repair mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding the role of R-loops in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Irvin, Elizabeth Marie — North Carolina State University Raleigh
- Study coordinator: Irvin, Elizabeth Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.