Understanding how specific proteins help neurons connect in the brain
Official title: Uncovering DIP-α signaling pathways underlying circuit assembly
Funded at University of Chicago · NIH-11008913 · Data updated 2026-11-12
This study looks at how certain proteins help brain cells connect with each other, which is important for how we think and behave, and by understanding this in fruit flies, we hope to learn more about similar processes in humans that could help people with neurological conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS136004-02 |
| Project ID | NIH-11008913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodevelopmental disorders such as autism spectrum disorder or neurodegenerative diseases like Alzheimer's.
✕Less likely to help
Patients with conditions unrelated to neural circuit assembly or those not experiencing cognitive or behavioral issues may not benefit from this research.
What this research studies
This research investigates the role of cell surface proteins in the assembly of neural circuits, which are crucial for behaviors and cognition. By studying the interactions of specific proteins, known as DIPs and Dprs, in the brains of fruit flies, the research aims to uncover how these proteins guide the connections between different types of neurons. The approach involves examining the signaling mechanisms that facilitate these connections, which could provide insights into similar processes in humans. Patients may benefit from a better understanding of neurological conditions linked to circuit assembly.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of neurodevelopmental and neurodegenerative disorders, potentially improving treatment strategies.
How similar studies have gone: Previous research has shown success in understanding neural connectivity through similar protein interactions, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Zhang, Ruiling — University of Chicago
- Study coordinator: Zhang, Ruiling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.