Understanding how specific proteins help heal the heart after injury
Official title: Chaperone-Mediated Autophagy in Cardiac Fibrosis
Funded at Albert Einstein College of Medicine · NIH-11133283 · Data updated 2026-11-12
This study is looking at how a special process in our cells helps heart repair after damage, like from a heart attack, and it focuses on understanding how this affects the cells that help heal the heart, especially in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $785,198 |
| NIH project number | 1R01HL174940-01A1 |
| Project ID | NIH-11133283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have experienced heart damage, such as from a heart attack.
✕Less likely to help
Patients with non-cardiac conditions or those who have not experienced heart damage may not benefit from this research.
What this research studies
This research investigates the role of Chaperone-Mediated Autophagy (CMA) in the healing process of the heart following damage, such as a heart attack. It focuses on how fibroblasts, which are crucial for heart repair, change their behavior and function during this process. By examining how CMA affects these cells, the research aims to uncover new insights into improving heart repair and function, especially in older patients where this process may be impaired. The study will involve various experimental approaches to analyze the effects of CMA on fibroblast activity and heart recovery.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart repair and function after injury, particularly for older patients.
How similar studies have gone: Previous research has shown that targeting cellular processes like CMA can improve heart repair, suggesting a promising avenue for this investigation.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Frangogiannis, Nikolaos G — Albert Einstein College of Medicine
- Study coordinator: Frangogiannis, Nikolaos G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.