Understanding how specific proteins help form connections in the retina
Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal Circuits
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10762975
This study is looking at how certain proteins in the eye help connect nerve cells that process what we see, which could help us understand eye diseases and vision problems better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10762975 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which certain proteins, known as Type II Cadherins, contribute to the precise wiring of retinal circuits in the eye. By using advanced genetic techniques, the study focuses on how these proteins influence the integration of different types of neurons that process visual information. The researchers aim to uncover the specific roles of two cadherins, Cdh9 and Cdh8, in directing the connections between retinal cells, which is crucial for normal vision. This work could lead to insights into how defects in these processes may result in various eye diseases and neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to retinal disorders or those experiencing unexplained vision problems.
Not a fit: Patients with fully developed retinal conditions that are not linked to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating eye diseases linked to retinal circuit defects.
How similar studies have performed: Previous research has shown promising results in understanding the role of cadherins in neural circuit formation, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUAN, XIN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: DUAN, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.