Understanding how specific proteins help fight herpes simplex virus in oral tissues
Official title: The role of caspase-3 mediated cleavage of VPS4A in restricting HSV-1
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11070271 · Data updated 2026-11-12
This study is looking at how certain proteins in our body can help fight the herpes virus in the mouth by triggering a type of cell death that stops the virus from spreading, which could lead to better ways to boost our natural defenses against infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | March 6, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $36,459 |
| NIH project number | 1F30AI188981-01 |
| Project ID | NIH-11070271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or currently experiencing herpes simplex virus infections, particularly in the oral cavity.
✕Less likely to help
Patients who do not have herpes simplex virus infections or related conditions may not benefit from this research.
What this research studies
This research investigates the role of caspases, which are proteins involved in programmed cell death, in controlling the replication of herpes simplex virus 1 (HSV-1) in the oral cavity. The study focuses on how these proteins can trigger a specific type of cell death that may help prevent the virus from spreading. By examining oral epithelial cells, the researchers aim to uncover the mechanisms that enhance antiviral defenses in mucosal tissues. This could lead to new insights into how the body naturally fights viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating herpes simplex virus infections.
How similar studies have gone: Previous research has shown that caspases play a role in antiviral defense, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Powers, Jennifer Lynn — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Powers, Jennifer Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.