Understanding how specific proteins control the development of retinal neurons.
Transcriptional control of retinal neuron specification and maturation.
This study is looking at how certain proteins help develop important nerve cells in the eye called amacrine cells, which play a key role in vision, to better understand eye diseases that can affect these cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11006346 on NIH RePORTER |
What this research studies
This research investigates the role of specific transcription factors in the development and maturation of amacrine cells, which are crucial inhibitory neurons in the retina. By examining how these proteins influence the genetic programs that dictate the formation and structure of these cells, the research aims to uncover the mechanisms behind their subtype specification. The study employs advanced techniques such as ATAC sequencing to analyze chromatin accessibility and gene expression patterns in retinal cells. Patients may benefit from insights gained into retinal diseases linked to amacrine cell dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with retinal disorders or those at risk of developing conditions that impact amacrine cell function.
Not a fit: Patients with retinal conditions unrelated to amacrine cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for retinal diseases that affect vision.
How similar studies have performed: Previous research has shown promising results in understanding retinal neuron development, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Wright, Kevin — Oregon Health & Science University
- Study coordinator: Wright, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.