Understanding how specific proteins control growth in cartilage cells
Transcriptional control of growth plate chondrocytes
This study is looking at how certain proteins help control the growth of cartilage in kids, which is important for their bone development, by using mouse models to see how these proteins work together and affect growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11101341 on NIH RePORTER |
What this research studies
This research investigates the role of transcription factors in the growth plates of cartilage, which are crucial for skeletal development in infants and children. It aims to understand how these proteins work together to regulate the differentiation of chondrocytes, the cells responsible for cartilage formation. The study will involve genetic experiments in mouse models to explore the interactions between these proteins and their effects on growth plate function. By profiling the genetic targets of these factors, the research seeks to uncover the mechanisms that ensure proper skeletal growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children experiencing growth plate-related issues or skeletal development disorders.
Not a fit: Patients with fully developed skeletal systems or those not experiencing growth-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for growth disorders in children.
How similar studies have performed: Previous research has shown promising results in understanding the roles of transcription factors in cartilage development, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lefebvre, Veronique M — Children's Hosp of Philadelphia
- Study coordinator: Lefebvre, Veronique M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.