Understanding how specific proteins control cell division
Spatiotemporal control of ubiquitination by phosphoinositide-binding proteins
['FUNDING_R01'] · CORNELL UNIVERSITY · NIH-11061213
This study is looking at how a protein called PLEKHA5 helps control cell division, which is important for understanding cancer and other diseases, and it’s designed for anyone interested in how our cells work and what can go wrong.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-11061213 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called PLEKHA5 in regulating the process of cell division, specifically how it interacts with the anaphase-promoting complex (APC/C), which is crucial for mitosis. By examining the spatial organization and timing of APC/C activity, the study aims to uncover how PLEKHA5 influences the access to substrates necessary for proper cell cycle progression. The research employs biochemical assays and molecular biology techniques to explore these interactions and their implications for cancer and other diseases related to cell cycle dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or conditions related to cell cycle dysregulation.
Not a fit: Patients with conditions unrelated to cell cycle regulation or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment by targeting the mechanisms that control cell division.
How similar studies have performed: Other research has shown success in understanding cell cycle regulation through similar molecular approaches, indicating a promising avenue for further exploration.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASKIN, JEREMY — CORNELL UNIVERSITY
- Study coordinator: BASKIN, JEREMY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.