Understanding how specific proteins control cell behavior in real-time
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
This study is looking at how certain proteins work together inside living cells, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11082380 on NIH RePORTER |
What this research studies
This research investigates the intricate interactions between guanine exchange factors (GEFs) and GTPases, which are proteins that play crucial roles in various cellular functions. By utilizing advanced imaging techniques and analytical methods, the study aims to visualize and analyze these interactions within living cells, focusing on processes like cell movement and adhesion. Patients may benefit from insights gained about how these proteins influence cancer progression and treatment responses, potentially leading to improved therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers that are influenced by GEF-GTPase signaling pathways.
Not a fit: Patients with conditions unrelated to GEF-GTPase interactions or those not diagnosed with cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by enhancing our understanding of cellular signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding cellular signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Danuser, Gaudenz — Ut Southwestern Medical Center
- Study coordinator: Danuser, Gaudenz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.