Understanding how specific proteins control a key enzyme involved in DNA replication and cancer development
Direct Control of the human CMG Helicase by Myc and Rb
This study is looking at how two proteins, Rb and Myc, affect an important enzyme that helps with DNA copying, which can be linked to cancer, to better understand how problems with these proteins might lead to cancer and help create new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10869881 on NIH RePORTER |
What this research studies
This research investigates the role of the CMG helicase, a crucial enzyme for DNA replication, and how it is regulated by two important proteins, Rb and Myc, which are linked to cancer. The study aims to uncover the molecular mechanisms by which these proteins influence the helicase's function, particularly during the cell cycle and in response to DNA damage. By examining these interactions, the research seeks to provide insights into how misregulation can lead to cancer progression, potentially paving the way for new therapeutic strategies. Patients may benefit from a better understanding of cancer mechanisms and the development of targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of inherited cancers or those diagnosed with malignancies linked to DNA replication issues.
Not a fit: Patients with cancers unrelated to DNA replication or those not exhibiting any genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with DNA replication errors.
How similar studies have performed: Previous research has shown that targeting the regulation of DNA replication enzymes can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Alexandrow, Mark G. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Alexandrow, Mark G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.