Understanding how specific proteins affect the survival and activation of immune cells
The Role of Pacs1-Wdr37 inLymphocyte Quiescence and Survival
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11005692
This study is looking at how two proteins, Pacs1 and Wdr37, help keep immune cells called lymphocytes in balance, which is important for fighting off illnesses, and it could lead to better treatments for autoimmune diseases and certain cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11005692 on ClinicalTrials.gov |
What this research studies
This research investigates the role of two proteins, Pacs1 and Wdr37, in maintaining the balance between quiescence and activation of lymphocytes, which are crucial immune cells. By studying how these proteins influence lymphocyte survival and response to signals, the research aims to uncover mechanisms that could lead to better treatments for immune-related conditions. The approach involves examining the effects of these proteins on B and T cells in laboratory settings, including their responses to stress and activation signals. Insights gained could help in understanding autoimmune diseases and lymphoid malignancies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune disorders or lymphoid malignancies.
Not a fit: Patients with unrelated health conditions or those not affected by immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and certain types of blood cancers by targeting the mechanisms of lymphocyte survival.
How similar studies have performed: Previous research has shown promising results in understanding lymphocyte behavior and survival, suggesting that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAIR-GILL, EVAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: NAIR-GILL, EVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.