Understanding how specific proteins affect RNA processing and quality control
Official title: Defining the biological roles of the 2',3'-cyclic phosphatases Angel1 and Angel2
Funded at University of California, San Diego · NIH-10904686 · Data updated 2026-11-12
This study is looking at how two proteins, Angel1 and Angel2, help keep RNA in our cells healthy, which could lead to better understanding and treatments for RNA-related diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 17, 2024 |
| Project end | January 16, 2027 |
| Funding year | 2025 |
| Award (this year) | $79,357 |
| NIH project number | 5F32GM151845-02 |
| Project ID | NIH-10904686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or diseases associated with RNA processing abnormalities.
✕Less likely to help
Patients with conditions unrelated to RNA processing or those not exhibiting any RNA dysfunction may not receive benefit from this research.
What this research studies
This research investigates the roles of two proteins, Angel1 and Angel2, in maintaining the quality of RNA within cells. By focusing on how these proteins interact with a specific RNA modification known as 2',3'-cyclic phosphate, the research aims to uncover mechanisms that ensure proper RNA function and degradation. The study employs advanced biochemical assays to analyze the activity of these proteins and their impact on cellular health. Patients may benefit from insights gained into RNA-related diseases caused by dysfunction in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to RNA dysfunction.
How similar studies have gone: While the specific focus on Angel1 and Angel2 is novel, similar research on RNA modifications has shown promising results in understanding cellular processes.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Dowdle, Megan Elizabeth — University of California, San Diego
- Study coordinator: Dowdle, Megan Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.