Understanding how specific proteins affect plant growth and development
Official title: Structural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in Plants
Funded at Duke University · NIH-11098225 · Data updated 2026-11-12
This study is looking at how two proteins, SPINDLY and SECRET AGENT, help plants like Arabidopsis grow and respond to their environment by changing other proteins, which could help us understand how plants adapt to different conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,565 |
| NIH project number | 3R01GM150029-02S1 |
| Project ID | NIH-11098225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be agricultural scientists and plant biologists interested in crop development and genetic engineering.
✕Less likely to help
Patients with no interest or involvement in plant biology or agriculture may not receive any benefit from this research.
What this research studies
This research investigates the roles of two important proteins, SPINDLY and SECRET AGENT, in the process of protein glycosylation in plants, specifically in Arabidopsis. By examining how these proteins modify transcription regulators, the research aims to uncover the molecular mechanisms that control plant growth and responses to environmental changes. The approach includes detailed structural and functional analyses of these proteins and their interactions with other cellular components. This could lead to insights into how plants adapt and develop under varying conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of plant growth regulation, potentially leading to improved agricultural practices and crop yields.
How similar studies have gone: While the specific focus on these glycosyltransferases may be novel, similar research in plant signaling and development has shown promising results in understanding plant biology.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Zhou, Pei — Duke University
- Study coordinator: Zhou, Pei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.