Understanding how specific proteins affect nerve cell growth and function
Investigating the Role and Regulation of the MAP7 Family Proteins in Axonal Morphogenesis and Function
This study is looking at how certain proteins help nerve cells grow and work properly, which could give us important clues about conditions that affect nerves and how we feel pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11004138 on NIH RePORTER |
What this research studies
This research investigates the role of a family of proteins known as MAP7 in the development and function of nerve cells. By studying how these proteins interact with microtubules and motor proteins, the research aims to uncover their influence on the growth of axons, which are crucial for nerve signaling. The approach includes using primary neuronal cell cultures and various assays to analyze protein functions and their effects on nerve cell morphology and transport mechanisms. This could lead to insights into neurodegenerative conditions and pain perception.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurodegenerative conditions or those experiencing chronic pain.
Not a fit: Patients with acute injuries or conditions unrelated to nerve cell function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases and pain management.
How similar studies have performed: Previous research has shown promising results in understanding the roles of microtubule-associated proteins in neuronal function, suggesting that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ma, Le — Thomas Jefferson University
- Study coordinator: Ma, Le
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.