Understanding how specific proteins affect heart development in embryos
Investigating the role of Yap/Taz in neural crest-derived cardiac development
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10999063
This study is looking at how certain proteins, called Yap and Taz, help form the heart from special cells in the body, and it aims to find out how problems with these proteins might lead to heart defects, which could help us understand and treat these issues better in the future.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10999063 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Yap and Taz proteins in the development of the heart from neural crest cells, which are crucial for proper heart formation. By using mouse models with specific genetic modifications, the study aims to uncover how disruptions in these proteins can lead to congenital heart defects. The research employs advanced techniques like ATAC sequencing to analyze gene regulation and cell behavior during heart development. Insights gained could help in understanding the onset of heart defects and potentially guide future therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include infants diagnosed with congenital heart defects or those with a family history of such conditions.
Not a fit: Patients with congenital heart defects not related to neural crest cell development may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital heart defects in newborns.
How similar studies have performed: Previous research has shown that understanding the molecular mechanisms behind heart development can lead to significant advancements in treating congenital heart defects.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ERHARDT, SHANNON NICOLE — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: ERHARDT, SHANNON NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.