Understanding how specific proteins affect gene regulation and cancer development
Decoding the Assembly and Function of Paralogue Specific SIN3A and SIN3B Human Chromatin Remodeling Complexes and Networks
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11087528
This study is looking at two proteins, SIN3A and SIN3B, to understand how they help control gene activity and cell structure, which is important for healthy development and can affect conditions like uterine cancer and certain developmental disorders, with the hope that this knowledge will lead to better treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11087528 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of two important proteins, SIN3A and SIN3B, in regulating gene expression and chromatin remodeling, which are crucial processes in both normal development and cancer. By examining how these proteins interact within large complexes, the research aims to uncover the mechanisms that lead to mutations associated with uterine cancer and neurodevelopmental disorders. The approach involves detailed molecular analysis and characterization of these protein complexes to identify their specific functions and regulatory roles. This knowledge could pave the way for targeted therapies in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with uterine corpus endometrial carcinoma or those with neurodevelopmental disorders potentially linked to SIN3A and SIN3B mutations.
Not a fit: Patients without any known genetic mutations in SIN3A or SIN3B or those not affected by related cancers or disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers linked to SIN3A and SIN3B mutations.
How similar studies have performed: While the specific focus on SIN3A and SIN3B is novel, previous research on chromatin remodeling complexes has shown promising results in understanding cancer mechanisms.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WASHBURN, MICHAEL P — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: WASHBURN, MICHAEL P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer type, Cancers