Understanding how specific proteins affect fat storage and metabolism
Molecular and cellular analysis of the ABHD5/PNPLA3 metabolon in lipid homeostasis
This study is looking at how certain proteins in your body affect fat storage and movement, especially in relation to fatty liver disease, to find new ways to help people with obesity and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10875530 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that regulate fat storage and mobilization in adipose tissue and the liver, which are crucial for maintaining metabolic health. It focuses on the interaction between two proteins, ABHD5 and PNPLA3, particularly a genetic variant of PNPLA3 that increases the risk of fatty liver disease. By studying how these proteins function and interact, the research aims to uncover new therapeutic targets for conditions like obesity and diabetes. Patients may benefit from insights that could lead to novel treatments for metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with obesity, diabetes, or fatty liver disease.
Not a fit: Patients who do not have metabolic disorders or related conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for obesity-related conditions such as diabetes and fatty liver disease.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism and its implications for metabolic diseases, suggesting that this approach has potential for success.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Mottillo, Emilio — Wayne State University
- Study coordinator: Mottillo, Emilio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.