Understanding how specific proteins affect facial development in embryos
Developmental roles of Nr2f1 and Nr2f2 in the vertebrate cranial neural crest
['FUNDING_FELLOWSHIP'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10842274
This study is looking at how two specific proteins, Nr2f1 and Nr2f2, help shape the face during development in zebrafish and mice, with the goal of understanding how changes in these proteins might lead to facial birth defects.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10842274 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of Nr2f1 and Nr2f2 proteins in the development of facial structures in vertebrates, particularly using zebrafish and mice as models. The study aims to understand how these proteins influence the formation of the cranial neural crest, which is crucial for proper facial development. By examining genetic mutations and their effects on facial structure, researchers will explore the underlying mechanisms that lead to birth defects. The approach includes genetic manipulation and detailed observation of developmental processes in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of craniofacial abnormalities or birth defects.
Not a fit: Patients with conditions unrelated to craniofacial development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of facial birth defects in humans.
How similar studies have performed: Other research has shown success in understanding genetic factors influencing craniofacial development, making this approach promising.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAULDING, DAVID — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: PAULDING, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.