Understanding how specific proteins affect brain development and learning.
Official title: PP2A B' subunit regulates synaptic development and cognition - learning fromhuman mutations
Funded at Lsu Health Sciences Center · NIH-11057960 · Data updated 2026-11-12
This study is looking at how a specific protein affects brain development and thinking skills, especially in people with intellectual disabilities, to help find better ways to understand and treat these challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | March 12, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $225,000 |
| NIH project number | 1R21NS137061-01A1 |
| Project ID | NIH-11057960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with intellectual disabilities or those who have genetic mutations linked to cognitive dysfunction.
✕Less likely to help
Patients without intellectual disabilities or cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of the PP2A B' subunit in brain development and cognitive function, particularly in relation to intellectual disability (ID). By studying mutations in specific genes linked to ID, the research aims to uncover the molecular mechanisms that connect these genetic changes to cognitive impairments. The approach includes using model organisms to observe how these proteins influence synaptic development and learning processes. The ultimate goal is to bridge the gap between genetic discoveries and potential treatments for cognitive dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapeutic strategies for individuals with intellectual disabilities.
How similar studies have gone: Previous research has shown promise in understanding the genetic basis of cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Wu, Chunlai — Lsu Health Sciences Center
- Study coordinator: Wu, Chunlai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.