Understanding how specific proteins affect brain communication in autism
Official title: The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3
Funded at University of Colorado Denver · NIH-11120279 · Data updated 2026-11-12
This study is looking at special proteins in the brain that help nerve cells talk to each other, and it aims to see how these proteins work differently in people with autism, which could help us understand autism better and find new ways to help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $422,280 |
| NIH project number | 1R21MH140328-01 |
| Project ID | NIH-11120279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the unique structures of proteins called neurexins that play a crucial role in how brain cells communicate. By using advanced imaging techniques, the study aims to visualize how these proteins cluster and interact at synapses, which are the connections between nerve cells. The goal is to uncover the mechanisms behind their organization and how they may differ in individuals with autism spectrum disorder. This could lead to a better understanding of the biological basis of autism and potential new avenues for treatment.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved therapies for individuals with autism spectrum disorder.
How similar studies have gone: Other research has shown promising results in understanding synaptic communication and its implications for autism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Aoto, Jason — University of Colorado Denver
- Study coordinator: Aoto, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.