Understanding how specific protein modifications affect gene expression and inheritance
Mechanism of Heterochromatin Assembly and epigenetic inheritance
['FUNDING_OTHER'] · COLUMBIA UNIV NEW YORK MORNINGSIDE · NIH-10895275
This study is looking at how certain chemical changes to proteins in our cells help control how genes are turned on or off, using a type of yeast to learn more about how these changes can be passed down through generations.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIV NEW YORK MORNINGSIDE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10895275 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone modifications, such as acetylation and methylation, in regulating chromatin structure and gene expression. Using fission yeast as a model, the project aims to uncover how these modifications are coordinated and how they influence the inheritance of gene expression states across generations. The study will explore the mechanisms by which certain modifications stimulate others, particularly focusing on the relationship between H3K14ub and H3K9 methyltransferases. By understanding these processes, the research seeks to shed light on the fundamental principles of epigenetic inheritance.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or diseases that may be influenced by epigenetic changes.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms or histone modifications may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of developmental disorders and diseases linked to defective histone modifications.
How similar studies have performed: Other research has shown success in understanding histone modifications and their roles in gene expression, indicating that this approach is built on established scientific principles.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIV NEW YORK MORNINGSIDE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIA, SONGTAO — COLUMBIA UNIV NEW YORK MORNINGSIDE
- Study coordinator: JIA, SONGTAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.