Understanding how specific protein modifications affect cell signaling and disease
Regulation and function of site-specific protein poly-ADP-ribosylation
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10877832
This study is looking at how a special change to proteins, called ADP-ribosylation, affects their function and could be linked to diseases like cancer and heart problems, with the hope that it will help create better treatments for patients dealing with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10877832 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein modification called ADP-ribosylation, which is crucial for various cellular processes. By studying how this modification affects different proteins, the research aims to uncover its implications in diseases such as cancer and cardiovascular disorders. The approach includes developing new methods to analyze how these modifications influence protein function and cellular signaling pathways. Patients may benefit from insights that could lead to targeted therapies for conditions related to DNA repair deficiencies and other diseases.
Who could benefit from this research
Good fit: Ideal candidates include individuals with DNA repair-deficient cancers or those affected by cardiovascular and neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein modifications or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and other diseases linked to protein modifications.
How similar studies have performed: Previous research has shown promise in targeting similar protein modifications for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LISZCZAK, GLEN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: LISZCZAK, GLEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.