Understanding how specific protein complexes regulate gene expression in cells
Official title: Elucidating pBAF-complex functions by chemical genetics and epigenome editing
Funded at Oklahoma Medical Research Foundation · NIH-11019322 · Data updated 2026-11-12
This study is looking at a special protein complex that helps control how our genes work, and it's hoping to find out how problems with this complex might lead to diseases like cancer and developmental disorders, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | June 10, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $341,000 |
| NIH project number | 1P20GM156711-01 |
| Project ID | NIH-11019322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or genetic disorders linked to chromatin regulation.
✕Less likely to help
Patients with conditions unrelated to chromatin dysregulation or those not diagnosed with cancer or genetic disorders may not benefit from this research.
What this research studies
This research investigates the functions of a specific protein complex known as the pBAF complex, which plays a crucial role in regulating gene expression and cellular processes. By using advanced techniques such as chemical genetics and epigenome editing, the researchers aim to uncover how this complex influences gene activity and chromatin structure. Patients may benefit from insights gained about how disruptions in these processes can lead to diseases like cancer and developmental disorders. The study will involve both loss-of-function and gain-of-function experiments to analyze the effects of these complexes on cellular behavior.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases caused by chromatin dysregulation, including various cancers.
How similar studies have gone: Previous research has shown promising results in understanding chromatin regulation and its implications for disease, indicating that this approach has potential for success.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Kirkland, Jacob Gordon — Oklahoma Medical Research Foundation
- Study coordinator: Kirkland, Jacob Gordon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.