Understanding how specific protein combinations form in cancer-related complexes
Official title: Molecular Basis of the Selective Assembly of Functionally Distinct PRC1s
Funded at Midwestern University (Glendale Az) · NIH-10515114 · Data updated 2026-11-12
This study is looking at how certain proteins work together in our cells and how their interactions might go wrong and lead to cancer, helping us understand more about what causes this disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Midwestern University (Glendale Az) NIH-funded |
| Lab location | 1 site (Glendale, United States) |
| Project start | September 22, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $450,000 |
| NIH project number | 1R15CA267804-01A1 |
| Project ID | NIH-10515114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may be influenced by the misregulation of chromatin and gene expression.
✕Less likely to help
Patients with cancers unrelated to the mechanisms of PRC1 or those not affected by chromatin regulation may not benefit from this research.
What this research studies
This research investigates the Polycomb repressive complex 1 (PRC1), a group of proteins that play a crucial role in regulating gene expression and chromatin structure. By examining how different proteins within PRC1 interact and assemble, the study aims to uncover the mechanisms that lead to misregulation associated with cancer. The researchers will utilize advanced techniques such as X-ray crystallography and biolayer interferometry to analyze these protein interactions and their implications for cellular differentiation. This work could provide insights into the fundamental processes that contribute to cancer development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer by understanding the molecular mechanisms behind PRC1 assembly.
How similar studies have gone: While the specific approach of investigating secondary protein interactions in PRC1 is novel, similar studies have shown success in understanding protein complexes in other contexts.
Where this research is happening
-
Midwestern University (Glendale Az)
Glendale, United States Active
Researchers
- Principal investigator: Kim, Chongwoo a — Midwestern University (Glendale Az)
- Study coordinator: Kim, Chongwoo a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.