Understanding how specific nerve cells contribute to migraine and facial pain.
Official title: The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain Conditions
Funded at University of Pennsylvania · NIH-10806545 · Data updated 2026-11-12
This study is looking at the nerve cells that play a role in migraines and facial pain to find new ways to help people who suffer from these headaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $6,751,538 |
| NIH project number | 1U19NS135528-01 |
| Project ID | NIH-10806545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who experience chronic migraines or facial pain.
✕Less likely to help
Patients with acute pain conditions unrelated to migraines or facial pain may not benefit from this research.
What this research studies
This research focuses on the complex neurological disorder of migraine, which affects many individuals and is linked to changes in nerve sensations in the face and head. The Penn Human Precision Pain Center aims to investigate the molecular and cellular characteristics of sensory neurons involved in migraine and facial pain by analyzing human tissue samples. The research will involve a multidisciplinary team and utilize advanced techniques to gather detailed information about these nerve cells under normal and migraine conditions. By understanding these mechanisms, the research seeks to identify potential new treatment targets for migraine sufferers.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for migraine and related facial pain conditions.
How similar studies have gone: Previous research has shown promise in understanding pain mechanisms through similar approaches, indicating potential for success in this area.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Luo, Wenqin — University of Pennsylvania
- Study coordinator: Luo, Wenqin
Related research
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This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.