Understanding how specific mutations in a protein can lead to cancer
Dissecting neomorphic functions mediated by mutant-specific structures of SPOP
This study is looking at how changes in a protein called SPOP can help us create better cancer treatments that target cancer cells while keeping healthy cells safe, and it could be especially helpful for people with prostate and endometrial cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11160102 on NIH RePORTER |
What this research studies
This research investigates the role of mutations in the SPOP protein, which is involved in regulating protein levels in cells. By examining how these mutations change the structure and function of SPOP, the researchers aim to develop targeted therapies that specifically attack cancer cells without harming normal cells. The study utilizes advanced techniques to analyze the protein's structure and its interactions with other molecules, which could lead to the creation of safer and more effective cancer treatments. Patients with certain types of cancer, such as prostate and endometrial cancer, may benefit from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with prostate, endometrial, or other solid tumors associated with SPOP mutations.
Not a fit: Patients without SPOP mutations or those with cancers not related to the ubiquitin-proteasome system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted cancer therapies that minimize side effects and improve treatment outcomes.
How similar studies have performed: Previous research has shown promise in developing targeted therapies for other mutations in the ubiquitin-proteasome system, indicating potential success for this novel approach.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mittag, Tanja — St. Jude Children's Research Hospital
- Study coordinator: Mittag, Tanja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.