Understanding how specific mutations in a cancer gene contribute to colorectal cancer development
Mechanisms of PIK3CA helical domain mutations driving colorectal tumorigenesis
This study is looking at how changes in a specific gene called PIK3CA, which is found in some colorectal cancer cases, can help tumors grow, and the researchers hope to create new treatments that target these changes to help patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10891501 on NIH RePORTER |
What this research studies
This research focuses on the role of mutations in the PIK3CA gene, which are found in about 30% of colorectal cancer cases. The team is investigating how these mutations, particularly in the helical domain of the gene, drive tumor growth through unique biological pathways. By studying the interactions of the mutated protein with other cellular components, the researchers aim to develop targeted therapies that could effectively treat patients with this specific mutation. The approach includes using inhibitors that block the activity of the mutated protein and its associated pathways to induce tumor regression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer who have specific mutations in the PIK3CA gene.
Not a fit: Patients with colorectal cancer that do not have PIK3CA mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for patients with PIK3CA-mutant colorectal cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar mutations in other cancers, suggesting potential for success in this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wang, Zhenghe — Case Western Reserve University
- Study coordinator: Wang, Zhenghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.