Understanding how specific mutations contribute to a type of T-cell lymphoma
Cooperative role of TET2 and IDH2 mutations in angioimmunoblastic T-cell lymphomagenesis
This study is looking into angioimmunoblastic T-cell lymphoma (AITL) to better understand how certain genetic changes affect the disease, with the hope of finding improved ways to diagnose and treat patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10911224 on NIH RePORTER |
What this research studies
This research investigates angioimmunoblastic T-cell lymphoma (AITL), a challenging subtype of peripheral T-cell lymphoma that is often difficult to diagnose and treat. The team uses advanced genomic techniques to identify mutations and pathways involved in the disease, focusing on the cooperative roles of TET2 and IDH2 mutations. By creating unique mouse models and patient-derived xenografts, they aim to uncover how these mutations affect T-cell behavior and contribute to lymphoma development. This work could lead to better diagnostic tools and targeted therapies for patients with AITL.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with angioimmunoblastic T-cell lymphoma or those exhibiting symptoms related to this condition.
Not a fit: Patients with other types of lymphomas or those without T-cell involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and more effective treatments for patients with angioimmunoblastic T-cell lymphoma.
How similar studies have performed: While the specific cooperative role of TET2 and IDH2 mutations in AITL is a novel approach, similar genomic studies have shown promise in understanding other hematological malignancies.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Iqbal, Javeed — University of Nebraska Medical Center
- Study coordinator: Iqbal, Javeed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.