Understanding how specific mRNA variants of a protein affect cell function and development
Isoform expression and post-transcriptional regulation of centrosomal plp mRNA
This study is looking at how a protein important for cell health, called Pericentrin-like protein (PLP), is made and controlled in different parts of the body, which could help us understand diseases like microcephaly and heart problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10646408 on NIH RePORTER |
What this research studies
This research investigates the regulation of a protein called Pericentrin-like protein (PLP) that is crucial for cell function and development. It focuses on how different forms of PLP mRNA are produced and how they are regulated in various tissues, which is important for understanding diseases linked to centrosome dysfunction. The study will involve identifying the mechanisms that control the localization and translation of PLP mRNA during embryonic development. By exploring these processes, the research aims to shed light on the role of PLP in conditions like microcephaly and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental disorders such as microcephaly or congenital diseases linked to centrosome dysfunction.
Not a fit: Patients with conditions unrelated to centrosome regulation or those who do not exhibit developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of developmental disorders and potential therapeutic targets for treatment.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring the role of centrosome components in developmental disorders.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Fang, Junnan — Emory University
- Study coordinator: Fang, Junnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.