Understanding how specific motor neurons control movement and breathing
Elucidating the Molecular and Functional Diversity of Axial Motor Neurons
This study is looking at how certain nerve cells that help us breathe and stand up develop and connect to muscles in mouse embryos, which could help us understand more about how these important movements work.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10998601 on NIH RePORTER |
What this research studies
This research investigates the axial neuromuscular system, which is crucial for essential motor behaviors like breathing and maintaining posture. The study aims to identify the molecular and functional diversity of motor neurons that control these movements, particularly focusing on how these neurons develop and connect to specific muscles. By using advanced techniques such as single nuclear RNA sequencing and immunohistochemistry, the research will characterize different types of motor neurons in mouse embryos, providing insights into their organization and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with motor disorders or conditions affecting muscle control and coordination.
Not a fit: Patients with purely neurological conditions unrelated to motor neuron function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of motor disorders affecting breathing and movement.
How similar studies have performed: Previous research has shown promising results in understanding motor neuron diversity and its implications for movement, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Adams, Alexandra a — New York University School of Medicine
- Study coordinator: Adams, Alexandra a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.