Understanding how specific microRNAs control gene expression and muscle cell development
Official title: Unraveling the biological roles of specific miRNAs, from experimental target identification through functional characterization
Funded at University of Colorado · NIH-11006356 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs, especially miR-1 and miR-206, help control muscle cell growth and development, which could lead to better understanding and treatments for muscle-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | March 10, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $282,775 |
| NIH project number | 5R01GM148613-03 |
| Project ID | NIH-11006356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting muscle development or function, such as muscular dystrophies.
✕Less likely to help
Patients with non-muscle related conditions or those not affected by muscle differentiation issues may not benefit from this research.
What this research studies
This research investigates the role of specific microRNAs, particularly miR-1 and miR-206, in regulating gene expression and muscle cell differentiation. By using cultured mouse muscle cells and in vivo experiments, the researchers aim to identify the mRNA targets of these microRNAs and understand how they influence cellular processes. The study employs advanced techniques to unravel the complex interactions between microRNAs and their targets, which could provide insights into muscle development and related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for muscle-related diseases by enhancing our understanding of muscle cell differentiation.
How similar studies have gone: Previous research has shown success in understanding the roles of microRNAs in various biological processes, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Kugel, Jennifer F. — University of Colorado
- Study coordinator: Kugel, Jennifer F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.