Understanding how specific ion channels in heart cells function in health and disease
Official title: Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytes
Funded at University of Wisconsin-Madison · NIH-11022196 · Data updated 2026-11-12
This study is looking at how certain heart cell channels, important for keeping your heart beating regularly, are made and work together, using heart cells grown from human stem cells, to help us understand heart rhythm problems better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,802 |
| NIH project number | 3K99HL169909-01S1 |
| Project ID | NIH-11022196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known cardiac arrhythmias or those at risk for developing heart conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those without any history of heart disease may not benefit from this research.
What this research studies
This research investigates the biogenesis of hERG1a and 1b ion channels, which are crucial for the electrical activity of heart cells. By studying cardiomyocytes derived from human induced pluripotent stem cells, the research aims to understand how these ion channels assemble and function properly. The approach includes examining the interactions between the mRNAs that encode these channels and identifying the proteins that assist in their assembly. This work could reveal important insights into the mechanisms behind cardiac arrhythmias and other heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with cardiac arrhythmias and other heart diseases.
How similar studies have gone: Previous research has shown success in understanding ion channel biogenesis and its implications for cardiac health, indicating that this approach is built on established findings.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Flores Aldama, Lisandra — University of Wisconsin-Madison
- Study coordinator: Flores Aldama, Lisandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.