Understanding how specific ion channels function in heart cells
Official title: Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytes
Funded at University of Wisconsin-Madison · NIH-10910127 · Data updated 2026-11-12
This study is looking at how important heart channels are made and work together, which could help us understand why some people have heart rhythm problems, and it might lead to new treatments for those conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $132,246 |
| NIH project number | 5K99HL169909-02 |
| Project ID | NIH-10910127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known cardiac arrhythmias or those at risk for developing such conditions.
✕Less likely to help
Patients without any cardiac conditions or those not experiencing arrhythmias may not benefit from this research.
What this research studies
This research investigates the biogenesis of hERG1a and 1b ion channels, which are crucial for the electrical activity of heart cells. By examining how these channels are formed and interact at the molecular level, the study aims to uncover the mechanisms that lead to cardiac arrhythmias. The research utilizes advanced techniques such as in vitro systems and calorimetry to analyze RNA interactions and protein assembly in human heart cells derived from induced pluripotent stem cells. Patients may benefit from insights gained into the causes of heart rhythm disorders and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with cardiac arrhythmias.
How similar studies have gone: Previous research has shown promising results in understanding ion channel biogenesis and its implications for cardiac health, indicating that this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Flores Aldama, Lisandra — University of Wisconsin-Madison
- Study coordinator: Flores Aldama, Lisandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.