Understanding how specific intestinal cells develop and function
Fate Specification of CFTR High Expresser Cells in the Intestine
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-11094720
This study is looking at special cells in the intestine that help keep things balanced and healthy, especially for people with cystic fibrosis, to learn how they develop and work, which could lead to better treatments for intestinal issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11094720 on ClinicalTrials.gov |
What this research studies
This research investigates a rare population of cells in the intestine known as CFTR High Expresser (CHE) cells, which are important for regulating pH levels. The study aims to uncover how these cells differentiate from stem cells and their role in maintaining intestinal health and disease, particularly in cystic fibrosis. By using advanced techniques to trace cell lineages and analyze their functions, the research seeks to provide insights into the mechanisms that govern these cells. This could lead to a better understanding of intestinal disorders and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cystic fibrosis or other related intestinal disorders.
Not a fit: Patients without cystic fibrosis or those not experiencing intestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cystic fibrosis and other intestinal diseases.
How similar studies have performed: While research on rare cell types is ongoing, this specific focus on CFTR High Expresser cells is relatively novel and has not been extensively studied.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAGOREN, ELEANOR — YALE UNIVERSITY
- Study coordinator: ZAGOREN, ELEANOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.