Understanding how specific intestinal cells develop and function
Official title: Fate Specification of CFTR High Expresser Cells in the Intestine
Funded at Yale University · NIH-11094720 · Data updated 2026-11-12
This study is looking at special cells in the intestine that help keep things balanced and healthy, especially for people with cystic fibrosis, to learn how they develop and work, which could lead to better treatments for intestinal issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $33,922 |
| NIH project number | 5F31DK137452-02 |
| Project ID | NIH-11094720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cystic fibrosis or other related intestinal disorders.
✕Less likely to help
Patients without cystic fibrosis or those not experiencing intestinal issues may not benefit from this research.
What this research studies
This research investigates a rare population of cells in the intestine known as CFTR High Expresser (CHE) cells, which are important for regulating pH levels. The study aims to uncover how these cells differentiate from stem cells and their role in maintaining intestinal health and disease, particularly in cystic fibrosis. By using advanced techniques to trace cell lineages and analyze their functions, the research seeks to provide insights into the mechanisms that govern these cells. This could lead to a better understanding of intestinal disorders and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cystic fibrosis and other intestinal diseases.
How similar studies have gone: While research on rare cell types is ongoing, this specific focus on CFTR High Expresser cells is relatively novel and has not been extensively studied.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Zagoren, Eleanor — Yale University
- Study coordinator: Zagoren, Eleanor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.