Understanding how specific immune receptors affect autoimmune diseases
Investigating How TLR7 Activates and TLR9 Regulates Systemic Autoimmunity
This study is looking at how two immune receptors, TLR7 and TLR9, work together in people with lupus to help find new ways to treat the disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11080778 on NIH RePORTER |
What this research studies
This research investigates the roles of two immune receptors, TLR7 and TLR9, in systemic lupus erythematosus (SLE), an autoimmune disease. The researchers aim to uncover how these receptors interact and influence disease progression, using advanced genetic models in mice to simulate human conditions. By studying these mechanisms, the research seeks to identify potential therapeutic targets that could lead to better treatments for patients with SLE.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or those with a family history of autoimmune diseases.
Not a fit: Patients with autoimmune conditions unrelated to systemic lupus erythematosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage or even prevent systemic lupus erythematosus.
How similar studies have performed: Previous research has shown promising results in understanding the roles of immune receptors in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Shlomchik, Mark J — University of Pittsburgh at Pittsburgh
- Study coordinator: Shlomchik, Mark J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.