Understanding how specific immune cells respond after a brain hemorrhage
Official title: Investigating the origin and role of the IgA+ B cell response to intracerebral hemorrhage
Funded at Yale University · NIH-11044980 · Data updated 2026-11-12
This study is looking at how certain immune cells in the brain might help people recover after a serious type of stroke called intracerebral hemorrhage, using mice to see when these cells show up and how they could support healing over 16 weeks.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS132530-02 |
| Project ID | NIH-11044980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage and are interested in understanding the immune response involved in their recovery.
✕Less likely to help
Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research investigates the role of IgA+ B cells in the brain following an intracerebral hemorrhage (ICH), a serious type of stroke. The study aims to determine when these immune cells enter the brain and how they may help in recovery after a stroke. Using a mouse model, researchers will track the influx of these cells over a period of 16 weeks to understand their potential neuroprotective functions. This could provide insights into new therapeutic strategies for improving recovery in stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce cognitive decline in stroke survivors.
How similar studies have gone: While the role of B cells in ischemic stroke has been studied, the specific investigation of IgA+ B cells in the context of intracerebral hemorrhage is novel and has not been extensively tested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ohashi, Sarah — Yale University
- Study coordinator: Ohashi, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.