Understanding how specific immune cells respond after a brain hemorrhage
Investigating the origin and role of the IgA+ B cell response to intracerebral hemorrhage
This study is looking at how certain immune cells in the brain might help people recover after a serious type of stroke called intracerebral hemorrhage, using mice to see when these cells show up and how they could support healing over 16 weeks.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11044980 on NIH RePORTER |
What this research studies
This research investigates the role of IgA+ B cells in the brain following an intracerebral hemorrhage (ICH), a serious type of stroke. The study aims to determine when these immune cells enter the brain and how they may help in recovery after a stroke. Using a mouse model, researchers will track the influx of these cells over a period of 16 weeks to understand their potential neuroprotective functions. This could provide insights into new therapeutic strategies for improving recovery in stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage and are interested in understanding the immune response involved in their recovery.
Not a fit: Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce cognitive decline in stroke survivors.
How similar studies have performed: While the role of B cells in ischemic stroke has been studied, the specific investigation of IgA+ B cells in the context of intracerebral hemorrhage is novel and has not been extensively tested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Ohashi, Sarah — Yale University
- Study coordinator: Ohashi, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.