Understanding how specific immune cells maintain gut health
Role of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue Homeostasis
This study is looking at special immune cells in the gut to understand how they help keep our gut healthy, and it aims to find out how energy production in these cells affects their ability to support gut health and manage immune responses, which could help patients learn more about maintaining a healthy gut.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10897893 on NIH RePORTER |
What this research studies
This research investigates the role of RORgt+ lymphocytes in maintaining the health of gut tissue. It focuses on how these immune cells, particularly gdT17 and ILC3 cells, function and interact with other cells in the gut environment. The study will explore the impact of mitochondrial function on these lymphocytes and their ability to regulate gut tissue remodeling and immune responses. Patients may benefit from insights into how gut health is maintained and how immune responses can be modulated.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting gut health or immune function.
Not a fit: Patients with no gastrointestinal issues or immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating gut-related diseases and improving overall gut health.
How similar studies have performed: Other research has shown promising results in understanding immune cell functions in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Zhou, Liang — University of Florida
- Study coordinator: Zhou, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.