Understanding how specific immune cells help maintain lung health during development
Characterizing Lung Resident B1 cells and their Impact on Lung Homeostasis during Development
['FUNDING_FELLOWSHIP'] · TUFTS UNIVERSITY BOSTON · NIH-11065775
This study is looking at special immune cells called B1 cells to understand how they help keep our lungs healthy and working well as we grow, which could help us learn more about lung protection and changes that happen with age.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11065775 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a unique type of immune cell, known as B1 cells, in maintaining lung health and function throughout development. The study aims to characterize these cells and their contributions to local immunity and inflammation regulation in the lungs. By utilizing advanced techniques such as single-cell RNA sequencing and flow cytometry, researchers will explore how these cells operate in both healthy and inflammatory conditions. This work could provide insights into the immune mechanisms that protect the lungs and how they may change with age.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of lung-related issues or those interested in understanding immune responses in lung health.
Not a fit: Patients with no lung health concerns or those who do not have a significant interest in immune system function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung diseases by enhancing our understanding of immune regulation in the lungs.
How similar studies have performed: While the role of B1 cells in other tissues has been studied, this specific investigation into their function in lung development is relatively novel and untested.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARROLL, KIMBERLY ANNE — TUFTS UNIVERSITY BOSTON
- Study coordinator: CARROLL, KIMBERLY ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.