Understanding how specific immune cells help maintain lung health during development
Official title: Characterizing Lung Resident B1 cells and their Impact on Lung Homeostasis during Development
Funded at Tufts University Boston · NIH-11065775 · Data updated 2026-11-12
This study is looking at special immune cells called B1 cells to understand how they help keep our lungs healthy and working well as we grow, which could help us learn more about lung protection and changes that happen with age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $45,162 |
| NIH project number | 1F31HL177963-01 |
| Project ID | NIH-11065775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of lung-related issues or those interested in understanding immune responses in lung health.
✕Less likely to help
Patients with no lung health concerns or those who do not have a significant interest in immune system function may not benefit from this research.
What this research studies
This research investigates the role of a unique type of immune cell, known as B1 cells, in maintaining lung health and function throughout development. The study aims to characterize these cells and their contributions to local immunity and inflammation regulation in the lungs. By utilizing advanced techniques such as single-cell RNA sequencing and flow cytometry, researchers will explore how these cells operate in both healthy and inflammatory conditions. This work could provide insights into the immune mechanisms that protect the lungs and how they may change with age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung diseases by enhancing our understanding of immune regulation in the lungs.
How similar studies have gone: While the role of B1 cells in other tissues has been studied, this specific investigation into their function in lung development is relatively novel and untested.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Carroll, Kimberly Anne — Tufts University Boston
- Study coordinator: Carroll, Kimberly Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.